--- title: "Case Study: Utilizing Bacillus velezensis PB6 as a therapeutic approach for treating diarrhea in nursery piglets" description: This case study examines the implementation of Bacillus velezensis PB6 to address increased diarrhea issues in piglets at a commercial farm in Italy. image: https://info.kemin.com/hubfs/KAE_Header%20banner%201_Pigs_shutterstock_1311114293.jpg --- [![Logo Kemin](https://info.kemin.com/hubfs/LLP/Logos/Logo-Kemin.svg) ](https://info.kemin.com/veterinary-nutritionals) Menu # Case Study: Utilizing Bacillus velezensis PB6 as a therapeutic approach for treating diarrhea in nursery piglets Published on **10-10-2024** - Written by **Kemin Animal Nutrition and Health** - [Pig](https://info.kemin.com/veterinary-nutritionals/blog/tag/pig) - [Management](https://info.kemin.com/veterinary-nutritionals/blog/tag/management) This case study examines the implementation of Bacillus velezensis PB6 to address increased diarrhea issues in piglets at a commercial farm in Italy. The goal was to resolve the diarrhea issues without antibiotic use. In November, the farm observed a significant increase in diarrhea among piglets. The diarrhea appeared immediately after birth and persisted until day five, affecting entire litters. Standard antibiotics, including enrofloxacin, florfenicol, and amoxicillin, were ineffective. The farm experienced moderate mortality, loss of condition, and lack of homogeneity among piglets. ## Identifying the Causes A thorough investigation was conducted to identify potential causes of the diarrhea. Various factors were examined, including agalactia, clostridia, coccidiosis, colibacillosis, PED virus, rotavirus, and TGE virus. The presence of *E.coli *ETEC strain K88 was confirmed, which was found to be sensitive to most antibiotics. *Clostridium difficile* was absent, but *Clostridium perfringens* was present in moderate levels. PRRS was confirmed positive with real-time PCR. ![pig1](https://info.kemin.com/hs-fs/hubfs/pig1.jpg?width=300&height=257&name=pig1.jpg)![Pig2-2](https://info.kemin.com/hs-fs/hubfs/Pig2-2.jpg?width=300&height=242&name=Pig2-2.jpg) ## Intervention To address these challenges, Bacillus velezensis PB6 as water-soluble concentrate, was introduced into the sow’s liquid feed at a concentration of 75 grams per ton. The treatment began seven days before farrowing and continued throughout the transition and lactation periods. ## Results and findings Thirty days after the initial outbreak and fifteen days post-treatment, nearly all clinical signs of diarrhea in newborn piglets had disappeared. The incidence of diarrhea was reduced to 5% of litters, and mortality rates returned to normal levels. Additionally, uniformity among piglets was re-established. The farmer observed and noted the effectiveness of Bacillus velezensis PB6 in addressing the health issues of the piglets. This case demonstrated the potential of Bacillus velezensis PB6 to significantly improve piglet health and reduce the reliance on antibiotics. ![Picture3](https://info.kemin.com/hs-fs/hubfs/Picture3.png?width=300&height=251&name=Picture3.png) ## Conclusion This case study demonstrates the effective use of Bacillus velezensis PB6 as a viable substitute for conventional antibiotic treatments in promoting piglet health. By modifying the microbiota of sows, Bacillus PB6 decreased E. coli excretion, thereby reducing the environmental challenges faced by piglets and addressing pre-weaning diarrhea issues. ## Also interesting [ 12-05-2025 - Written by Kemin Animal Nutrition and Health ##### Kemin, Gold Sponsor of ESPHM 2025 At ESPHM 2025, we highlight innovations to support gut health, boost performance, and reduce antibiotic reliance across all stages of pig production. 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